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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2S2
All Species:
48.18
Human Site:
S310
Identified Species:
81.54
UniProt:
P20042
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P20042
NP_003899.2
333
38388
S310
E
T
C
H
S
R
C
S
V
A
S
I
K
T
G
Chimpanzee
Pan troglodytes
NP_001092026
333
38354
S310
E
T
C
H
S
R
C
S
V
A
S
I
K
T
G
Rhesus Macaque
Macaca mulatta
XP_001105021
327
37615
S304
E
T
C
H
S
R
C
S
V
A
S
I
K
T
G
Dog
Lupus familis
XP_534387
333
38269
S310
E
T
C
H
S
R
C
S
V
A
S
I
K
T
G
Cat
Felis silvestris
Mouse
Mus musculus
Q99L45
331
38074
S308
E
T
C
H
S
R
C
S
V
A
S
I
K
T
G
Rat
Rattus norvegicus
NP_955412
333
38225
S310
E
T
C
H
S
R
C
S
V
A
S
I
K
T
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510012
334
38349
S311
E
T
C
H
S
R
C
S
V
A
S
I
K
T
G
Chicken
Gallus gallus
NP_989928
334
38418
S311
E
T
C
H
S
R
C
S
V
A
S
I
K
T
G
Frog
Xenopus laevis
NP_001090286
332
38131
S309
E
T
C
H
S
R
C
S
V
A
S
I
K
T
G
Zebra Danio
Brachydanio rerio
NP_997840
327
37446
S304
E
T
C
H
S
R
C
S
V
A
S
I
K
T
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P41375
312
35199
S289
E
S
C
G
S
R
C
S
V
A
S
I
K
S
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21230
250
27561
S228
C
S
V
T
A
I
K
S
G
F
K
A
V
V
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q41969
268
30644
S248
L
R
C
E
K
C
G
S
Q
R
S
V
A
P
I
Baker's Yeast
Sacchar. cerevisiae
P09064
285
31556
T265
V
C
K
S
C
G
S
T
R
S
V
S
S
I
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.9
98.1
N.A.
95.5
96.6
N.A.
96.7
94.3
87.6
77.7
N.A.
58.2
N.A.
45.3
N.A.
Protein Similarity:
100
99.6
98.1
99.4
N.A.
98.1
98.5
N.A.
98.1
96.7
92.1
87.3
N.A.
69.9
N.A.
56.7
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
80
N.A.
13.3
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
93.3
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.2
39.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59.4
54.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
0
0
0
79
0
8
8
0
0
% A
% Cys:
8
8
86
0
8
8
79
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
79
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
8
8
0
8
0
0
0
0
0
86
% G
% His:
0
0
0
72
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
8
0
0
0
0
0
79
0
8
8
% I
% Lys:
0
0
8
0
8
0
8
0
0
0
8
0
79
0
8
% K
% Leu:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% Q
% Arg:
0
8
0
0
0
79
0
0
8
8
0
0
0
0
0
% R
% Ser:
0
15
0
8
79
0
8
93
0
8
86
8
8
8
0
% S
% Thr:
0
72
0
8
0
0
0
8
0
0
0
0
0
72
0
% T
% Val:
8
0
8
0
0
0
0
0
79
0
8
8
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _